Review



pac 1  (MedChemExpress)


Bioz Verified Symbol MedChemExpress is a verified supplier
Bioz Manufacturer Symbol MedChemExpress manufactures this product  
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 94
      Buy from Supplier

    Structured Review

    MedChemExpress pac 1
    Pac 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 16 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1/pmc13429674-273-10-13
    Average 94 stars, based on 16 article reviews
    pac 1 - by Bioz Stars, 2026-09
    94/100 stars

    Images

    Related Articles

    other:


    In Vivo:

    Article Title: Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells
    Article Snippet: Metastasis development is the leading cause of cancer-related mortality in pancreatic ductal adenocarcinoma (PDAC) and yet, few preclinical systems to recapitulate its full spreading process are available.. Thus, modeling of tumor progression to metastasis is urgently needed.. In this work, we describe the generation of highly metastatic PDAC patient-derived xenograft (PDX) mouse models and subsequent single-cell RNA-sequencing (RNA-seq) of circulating tumor cells (CTC), isolated by human HLA sorting, to identify altered signaling and metabolic pathways, as well as potential therapeutic targets.

    Saline:

    Article Title: Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells
    Article Snippet: Metastasis development is the leading cause of cancer-related mortality in pancreatic ductal adenocarcinoma (PDAC) and yet, few preclinical systems to recapitulate its full spreading process are available.. Thus, modeling of tumor progression to metastasis is urgently needed.. In this work, we describe the generation of highly metastatic PDAC patient-derived xenograft (PDX) mouse models and subsequent single-cell RNA-sequencing (RNA-seq) of circulating tumor cells (CTC), isolated by human HLA sorting, to identify altered signaling and metabolic pathways, as well as potential therapeutic targets.

    In Situ:

    Article Title: Discovery of New Targets to Control Metastasis in Pancreatic Cancer by Single-cell Transcriptomics Analysis of Circulating Tumor Cells
    Article Snippet: Metastasis development is the leading cause of cancer-related mortality in pancreatic ductal adenocarcinoma (PDAC) and yet, few preclinical systems to recapitulate its full spreading process are available.. Thus, modeling of tumor progression to metastasis is urgently needed.. In this work, we describe the generation of highly metastatic PDAC patient-derived xenograft (PDX) mouse models and subsequent single-cell RNA-sequencing (RNA-seq) of circulating tumor cells (CTC), isolated by human HLA sorting, to identify altered signaling and metabolic pathways, as well as potential therapeutic targets.

    Transfection:

    Article Title: Apoptosis of Mdm2 -deficient osteocytes enhances osteogenesis through TRPM8-enriched apoptotic vesicles
    Article Snippet: .. Scramble siRNA transfected MLO-Y4 cells were treated with or without PAC-1 (100 μmol/L, MedChemExpress). ..



    Similar Products

    pac 1  (MedChemExpress)
    94
    MedChemExpress pac 1
    Pac 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1/pmc13429674-273-10-13
    Average 94 stars, based on 1 article reviews
    pac 1 - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier
    class c β lactamase pac 1  (Janvier Labs)
    86
    Janvier Labs class c β lactamase pac 1
    Class C β Lactamase Pac 1, supplied by Janvier Labs, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/1+c+class+lactamase+pac+%CE%B2/pm42237234-394-16-10
    Average 86 stars, based on 1 article reviews
    class c β lactamase pac 1 - by Bioz Stars, 2026-09
    86/100 stars
    		  Buy from Supplier
    pac1 receptor agonist  (Tocris)
    94
    Tocris pac1 receptor agonist
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Pac1 Receptor Agonist, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC+1/pmc13039158-114-5-19
    Average 94 stars, based on 1 article reviews
    pac1 receptor agonist - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier
    vad pac 1 selleckchem cat  (Selleck Chemicals)
    93
    Selleck Chemicals vad pac 1 selleckchem cat
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Vad Pac 1 Selleckchem Cat, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1/pm41762656-248-283-285
    Average 93 stars, based on 1 article reviews
    vad pac 1 selleckchem cat - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier
    anti pac 1  (Santa Cruz Biotechnology)
    92
    Santa Cruz Biotechnology anti pac 1
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Anti Pac 1, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 92/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC+1/10__1177_slash_1096620x261422285-29-8-30
    Average 92 stars, based on 1 article reviews
    anti pac 1 - by Bioz Stars, 2026-09
    92/100 stars
    		  Buy from Supplier
    anti dusp2  (Santa Cruz Biotechnology)
    93
    Santa Cruz Biotechnology anti dusp2
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Anti Dusp2, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1+Antibody/pmc12856980-61-79-81
    Average 93 stars, based on 1 article reviews
    anti dusp2 - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier
    horseradish peroxidase hrp  (Santa Cruz Biotechnology)
    93
    Santa Cruz Biotechnology horseradish peroxidase hrp
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Horseradish Peroxidase Hrp, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1+Antibody/pmc12856980-61-89-94
    Average 93 stars, based on 1 article reviews
    horseradish peroxidase hrp - by Bioz Stars, 2026-09
    93/100 stars
    		  Buy from Supplier
    compound 1 pac 1  (MedChemExpress)
    94
    MedChemExpress compound 1 pac 1
    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of <t>PAC1</t> receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.
    Compound 1 Pac 1, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/pac+1/PAC-1/pm41422996-56-1-9
    Average 94 stars, based on 1 article reviews
    compound 1 pac 1 - by Bioz Stars, 2026-09
    94/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of PAC1 receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.

    Journal: Translational Psychiatry

    Article Title: The ventral hippocampus to paraventricular thalamus circuit regulates context-dependent hyperlocomotion through PAC1 receptor signaling in the chronic stress-induced PTSD mouse model

    doi: 10.1038/s41398-026-03963-1

    Figure Lengend Snippet: (A) The immunofluorescent staining showed that CSDS treatment induced obvious increases in the expression of PAC1 receptor within PVT neurons (upper panel, amplification: 4 x; lower panel, amplification: 60 x). (B) The western blot revealed the apparent increases in the PAC1 receptor within PVT region and (C) the statistical analysis ( n = 5 mice for each group; Mann-Whitney unpaired two-tailed U test; U = 0, ** p = 0.0079). (D) The experimental strategy of cannula injection of PAC1 receptor antagonist and behavioral tests. (E) The context-dependent locomotion activity (One-way ANOVA with Tukey post-hoc test, F(2, 21.47) = 9.201, ** p = 0.0013; Ctrl vs. CSDS, * p = 0.0429; CSDS vs. CSDS + PA-915, *** p = 0.0006). (F) The time spent in open arm (One-way ANOVA with Tukey post-hoc test, F(2, 24.69) = 9.033, ** p = 0.0011; Ctrl vs. CSDS, ** p = 0.0041; CSDS vs. CSDS + PA-915, * p = 0.0163) and (G) number of open arm entries (One-way ANOVA with Tukey post-hoc test, F(2, 26.45) = 6.594, ** p = 0.0047; Ctrl vs. CSDS, * p = 0.0107; CSDS vs. CSDS + PA-915, * p = 0.0193) in the elevated plus maze test. (H) The sociability in the three-chamber test (One-way ANOVA with Tukey post-hoc test, F(2, 17.81) = 6.317, ** p = 0.0084; Ctrl vs. CSDS, * p = 0.0189; CSDS vs. CSDS + PA-915, * p = 0.0173) and (I) the innate motivation in the female encounter test (One-way ANOVA with Tukey post-hoc test, F(2, 22.87) = 7.469, ** p = 0.0032; Ctrl vs. CSDS, * p = 0.0122; CSDS vs. CSDS + PA-915, * p = 0.0102). (J) The arousal levels (One-way ANOVA with Tukey post-hoc test, F(2, 24.94) = 5.412, * p = 0.0112; Ctrl vs. CSDS, * p = 0.044; CSDS vs. CSDS + PA-915, * p = 0.0316). Data was represented as mean ± SD from three independent experiments. n = 10 mice per group per experiment.

    Article Snippet: To test the effect of PAC1 receptor agonist and antagonist on the PVT neuronal activity, both PA-915 and maxadilan (Tocris Biosciences) were finally dissolved in ACSF at 5, 20, 50, 100 nM to examine the changes of PVT neuronal firings.

    Techniques: Staining, Expressing, Amplification, Western Blot, MANN-WHITNEY, Two Tailed Test, Injection, Activity Assay